and triflouroacetic acid cleavage are employed for peptide
syntheses. Crude peptides are purified by preparative HPLC
using reverse phase C18 columns and the purity grade (90-95%)
checked by analytical HPLC and mass spec.
We can provide peptides with coded and non coded amino acids,
cyclic peptide (disulfide bond), peptide with modified peptide
bond and labelled peptide with biotin and fluorescein.
Determination of pharmacological profile of new substances
with standard biological tests in vitro and in vivo available
in UFPeptides laboratories.
Setting up of new in vivo and in vitro pharmacological test
for determination of pharmacological profile of new substances;
planning and realization of target validation studies.
Integrated development of drug design
and target validation studies.
This type of projects can be performed by UFPeptides
either as full service contract
or in partnership with a distinct pharmaceutical industry.
The development of such projects will be extremely facilitated
by the close collaboration between UFPeptides
chemists and pharmacologists; this
will increase the success possibilities reducing at the same
time the working time / single project.